Reagent selection is a key decision in determining safety precautions needed when running a reaction. The e-Encyclopedia of Reagents for Organic Synthesis includes safety information. For organic and organometallic reactions, starting with Science of Synthesis (SoS) is useful because of the amount of detail provided and recommendations on the best way to do a particular reaction. Safety warnings are integrated into the text of SoS. For SciFinder and Reaxys, it is possible to see which reagents were used in reactions. While both SciFinder and Reaxys include organic and organometallic reactions, Reaxys is the only structure searchable database for inorganic reactions.
For more resources, please see Chemistry & Chemical Engineering - Syntheses & reactions.